Three- versus four-factor prothrombin complex concentrate for the reversal of warfarin-induced bleeding
نویسندگان
چکیده
منابع مشابه
Comparison of 3-Factor Prothrombin Complex Concentrate and Low-Dose Recombinant Factor VIIa for Warfarin Reversal
INTRODUCTION Prothrombin complex concentrate (PCC) and recombinant Factor VIIa (rFVIIa) have been used for emergent reversal of warfarin anticoagulation. Few clinical studies have compared these agents in warfarin reversal. We compared warfarin reversal in patients who received either 3 factor PCC (PCC3) or low-dose rFVIIa (LDrFVIIa) for reversal of warfarin anticoagulation. METHODS Data were...
متن کاملOutcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department.
BACKGROUND Physicians reverse patients' warfarin anticoagulation with frozen plasma or prothrombin complex concentrate. Our objective was to determine adverse event frequency after urgent reversal with frozen plasma versus the prothrombin complex concentrate Octaplex. METHODS AND RESULTS This natural before-after retrospective cohort study in 2 tertiary care emergency departments compared ant...
متن کاملActivated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for the reversal of warfarin-induced coagulopathy
AIMS The purpose of this study was to evaluate the effectiveness of a new, fixed, yet individualized dosing regimen of activated prothrombin complex concentrate factor VIII inhibitor bypassing activity (FEIBA) for warfarin reversal in the setting of a life-threatening bleeding in a secondary care center. METHODS In this report we present a retrospective chart review of 72 patients who receive...
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V itamin K antagonists (VKAs), such as warfarin, are widely used for prevention and treatment of arterial and venous thrombosis. Although oral or intravenous vitamin K and fresh frozen plasma are often used to reverse the antico-agulant effects of warfarin in patients who are bleeding, this approach has important limitations. Restoration of hemosta-sis with vitamin K relies on the hepatic synth...
متن کاملEffective reversal of edoxaban-associated bleeding with four-factor prothrombin complex concentrate in a rabbit model of acute hemorrhage.
BACKGROUND Edoxaban is an oral, selective direct factor Xa inhibitor approved in Japan for venous thromboembolism prevention after orthopedic surgery. Data are lacking regarding reversal strategies for edoxaban; this study assessed whether four-factor prothrombin complex concentrate (Beriplex/Kcentra; CSL Behring GmbH, Marburg, Germany) can effectively reverse its effects on hemostasis using a ...
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ژورنال
عنوان ژورنال: International Journal of Critical Illness and Injury Science
سال: 2018
ISSN: 2229-5151
DOI: 10.4103/ijciis.ijciis_40_17